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KMID : 1098420080160040255
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Korean Journal of Medicinal Crop Science
2008 Volume.16 No. 4 p.255 ~ p.260
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Skin-Whitening and UV-Protective Effects of Angelica gigas Nakai Extracts on Ultra High Pressure Extraction Process
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Kim Cheol-Hee
Kwon Min-Cheol
Han Jae-Gun
Na Chun-Su
Kwak Hyeong-Geun
Choi Geun-Pyo
Park Uk-Yeon
Lee Hyeon-Yong
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Abstract
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This study was performed to investigate the enhancement of UV-protection activities and skin-whitening effects from Angelica gigas Nakai extracts on ultra high pressure extraction process. Extraction at treated by ultra high pressure for 15 minute and associated with ultrasofication (HPE15) was showed more than double yield, compare conventional extraction, as 12.24% (w/w) from A. gigas. Extracts of HPE15 reduced expression of MMP-1 on UV-irradiated CCD-986sk cells as 122.2% and revealed high inhibitory potency on tyrosinase as 69.4% by adding samples. Extracts of HPE15 from A. gigas showed strong inhibition effect on melanin production test by Clone M-3 cells as 82.4% by adding extracts. From the preliminary observations, we considered that the extracts from A. gigas could be potent natural materials for skin-whitening agent, and could be used as a potential anti-aging agent for the photo-damaged skin.
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KEYWORD
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Angelica gigas Nakai, Ultra High Pressure, UV Protection, Skin-Whitening
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